The protective role of resveratrol against zinc oxide induced nanotoxicity

Authors : Buğrahan EMSEN, Hasan TÜRKEZ

Pages : 21-25

Doi:10.30616/ajb.343665

View : 37 | Download : 6

Publication Date : 2017-11-30

Article Type : Research Paper

Abstract :Zinc oxide insert ignore into journalissuearticles values(ZnO); is a compound that has harmful effects as well as being used in many different areas. Numerous studies have been carried out to minimize the toxic effects of ZnO nanoparticles insert ignore into journalissuearticles values(NPs);. In the present study, the protective role of resveratrol insert ignore into journalissuearticles values(RSV);, a potent antioxidant polyphenol substance, was examined against ZnO-induced nanotoxicity on human pulmonary alveolar epithelial cells insert ignore into journalissuearticles values( HPAEpiC );. In this context, the cytotoxic and genotoxic effects of different concentrations of RSV insert ignore into journalissuearticles values(5, 10, 20 mg/L); and ZnO NPs on the cells were measured alone and in combination . At the same time, the effects of aforementioned applications on the total antioxidant capacity insert ignore into journalissuearticles values(TAC); level in HPAEpiC were assessed. The results obtained showed that ZnO NPs alone significantly increased cytotoxicity and genotoxicity on cells compared to negative control insert ignore into journalissuearticles values(control insert ignore into journalissuearticles values(-););. In the experiments performed with RSV + ZnO NP combination, cytotoxic and genotoxic activity decreased at the level of p < 0.05 especially at 20 mg/L application of RSV. When the level of TAC in cells was examined, a concentration-dependent increase was detected between TAC and RSV. It was determined that Zno NPs reduced the TAC level statistically insert ignore into journalissuearticles values( p < 0.05); in comparison with control insert ignore into journalissuearticles values(-);. In conclusion, the present study revealed that RSV, a natural antioxidant, showed protective property against genotoxic and cytotoxic damage induced by ZnO NPs on HPAEpiC .
Keywords : Antioxidant, Nanotoxicity, Resveratrol, Zinc oxide

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