Synthesis, Characterization and Antiviral Activities of Some Novel 4-Thiazolidinones Derived from Imidazo[2,1-b][1,3]thiazole-5-carbohydrazide Hydrazones

Authors : Mine ISAOGLU, Nesrin CESUR

Pages : 22-30

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Publication Date : 2020-06-30

Article Type : Research Paper

Abstract :The present study describes the synthesis, characterization and antiviral activity evaluation of some novel 5-insert ignore into journalissuearticles values(nonsubstitue/methyl);-4-oxo-2-insert ignore into journalissuearticles values(substituted phenyl);-1,3-thiazolidine-4-one derivatives bearing an imidazo[2,1-b][1,3]thiazole-5-carboxamide moiety at N-3 position of the 4-thiazolidinone ring. The structures of the new 4-thiazolidinone compounds were confirmed by the data obtained from elemental analysis, IR, 1H-NMR, 13C-NMR insert ignore into journalissuearticles values(proton decoupled); and 13C-NMR insert ignore into journalissuearticles values(APT); spectra. The cytotoxicities and antiviral activities of 4-thiazolidinones were evaluated in-vitro against different types of DNA and RNA viruses in different cell cultures. Neither of the compounds had anti-influenza and anti-HIV activities, but 4c and 5d showed some degree of antiviral activity against the other tested virus types.
Keywords : Drug research, Carbonyl compounds, 4 Thiazolidinones, Hydrazide hydrazones, Antiviral activity