Study of Stability and Drug-Excipient Compatibility of Estriol

Home Page
About
Submit A Journal
Submit A Conference
Submit Paper/Book
- Submit a Preprint
- Submit a Book
Contact

Bilge International Journal of Science and Technology Research
Volume:3 Issue:2
Study of Stability and Drug-Excipient Compatibility of Estriol

Study of Stability and Drug-Excipient Compatibility of Estriol

Authors : Hale SEÇİLMİŞ CANBAY, Mümin POLAT, Mahmut DOĞANTÜRK

Pages : 102-107

Doi:10.30516/bilgesci.582054

View : 26 | Download : 11

Publication Date : 2019-09-30

Article Type : Research Paper

Abstract :Abstract: Estriol , is a major urinary estrogen hormone . Differential scanning calorimetry insert ignore into journalissuearticles values(DSC); and Fourier-transform infrared spectroscopy insert ignore into journalissuearticles values( FTIR ); were used to assess the compatibility between estriol and drug excipients insert ignore into journalissuearticles values(1:1; w/w);. In this study, thermodynamic and spectroscopic data obtained from pure estriol and mixtures of pure estriol with pharmaceutical excipients were compared. Preliminary studies using thermal and spectroscopic technique implied the compatibility of mannitol, calcium phosphate dibasic, sucrose, butylated hydroxyanisole, cellulose, lactose, magnesium stearate, talc and sodium carboxymethyl cellulose with the drug estriol. As a result of the experimental study, there is incompatibility of estriol-mannitol, estriol-sucrose, estriol-lactose and estriol-magnesium stearate . Keywords Estriol, Stability Compatibility, DSC, FTIR
Keywords : DSC, Compatibility, Stability, FTIR

ORIGINAL ARTICLE URL

VIEW PAPER (PDF)

* There may have been changes in the journal, article,conference, book, preprint etc. informations. Therefore, it would be appropriate to follow the information on the official page of the source. The information here is shared for informational purposes. IAD is not responsible for incorrect or missing information.