- Caucasian Journal of Science
- Volume:7 Issue:2
- Effect of ACE Plus Selenium on Total Antioxidant/Oxidant Capacity and Nitric Oxide Levels in Rabbits
Effect of ACE Plus Selenium on Total Antioxidant/Oxidant Capacity and Nitric Oxide Levels in Rabbits
Authors : Ahmet HARMANKAYA, Ayla ÖZCAN, Rüya KAYA, Çağatay ÖZBEY, Onur ATAKİSİ, Kezban DALGINLI
Pages : 123-129
Doi:10.48138/cjo.830176
View : 47 | Download : 9
Publication Date : 2020-12-31
Article Type : Research Paper
Abstract :Pills including vitamins and minerals have been used as part of sedentary lifestyle, malnutrition, aging, and of age-related ilnesses in developed countries. This study specefically focuses on the effect of ACE Plus Selenium given rabbits through intraperitoneal insert ignore into journalissuearticles values(i.p); injection on their total oxidant, antioxidant capacity insert ignore into journalissuearticles values(TOC, TAC);, and nitric oxide insert ignore into journalissuearticles values(NO); levels.In this study, 0,5 ml/kg of normal saline was injected to rabbits in control group and 0,5 ml/kg of ACE Plus Selenium was conducted to the treatment group for twice insert ignore into journalissuearticles values(every other day); via i.p route. Following the injection, plasmas of blood samples obtained in the second and fourth days, were seperated, and stored at -20ºC till the analysis. Plasma TAC, TOC and NO levels were determined spectrophotometrically. The TOC, TAC and NO levels of the rabbits were compared to the control group statistically. While TOC levels were observed to decrease insert ignore into journalissuearticles values(p<0,05); on the fourth day, the NO levels increased insert ignore into journalissuearticles values(p<0,01); on the second day and became normal on the fourth day. Further no statistical alteration was observed in the TAC levels. As a result, it can be concluded that ACE Plus Selenium had no effect on TAC level, it may decrease TOC levels in parallel to the decline in oxidative stress; further it can increase NO levels acutely as a result of α-tocopherol and ascorbat ingredients.Keywords : Multivitamin, oxidative stress, antioxidant, nitric oxide
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