Synthesis and Biological Evaluation of 3-Alkyl(Aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one Derivatives

Authors : Özlem Gürsoy Kol, Fevzi Aytemiz, Sevda Manap, Haydar Yüksek

Pages : 50-57

Doi:10.48138/cjo.1484675

View : 32 | Download : 23

Publication Date : 2024-08-02

Article Type : Research Paper

Abstract :In the present study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (3c, f, e) reacted with 4-methylthiobenzaldehyde to afford 3-alkyl(aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-ones (4c, f, e). The structures of three new compounds were established from the elemental analysis, IR, 1H NMR, and 13C NMR spectral data. The newly synthesized and recently synthesized 3-alkyl(aryl)-4-(4-methylthiobenzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one derivatives were analyzed using three methods for antioxidant activities. Compound 4a showed the best activity for the metal chelating effect. Furthermore, the compounds\' antimicrobial activity was screened.
Keywords : 1, 2, 4 triazole, Synthesis, Antioxidant activity, Antimicrobial activity