Delta values as a prognostic marker in methanol poisoning: a retrospective cohort study

Authors : Murat DUYAN, Ali SARIDAŞ, Nafis VURAL

Pages : 46-53

Doi:10.17826/cumj.1173429

View : 24 | Download : 13

Publication Date : 2023-03-31

Article Type : Research Paper

Abstract :Purpose: The aim of the study was to evaluate the mortality prediction performances of delta bicarbonate, delta anion gap, and delta ratio in methanol poisoning insert ignore into journalissuearticles values(MP); cases. Materials and Methods: This clinical study, which followed a cross-sectional study design, involved patients with MP who were still alive when they initially arrived at the emergency department of a tertiary care hospital. Patients were divided into two groups mortality and non-mortality. Patients who died during treatment and follow-up were assigned to the mortality group, while others were assigned to the non-mortality group. Receiver Operating Characteristic insert ignore into journalissuearticles values(ROC); analysis was used to determine the cut-off in the diagnostic value measurements of biomarkers predicting mortality. Results: Nine insert ignore into journalissuearticles values(20%); of the 45 patients in the study died during their follow-up. The two groups showed a significant difference in the averages of pH, bicarbonate insert ignore into journalissuearticles values(HCO3-);, lactate, anion gap, delta anion gap, delta HCO3-, and delta ratio, but not in the averages of partial carbon dioxide pressure insert ignore into journalissuearticles values(pCO2);. In predicting mortality, pH, anion gap, and delta anion gap were found to have outstanding diagnostic power insert ignore into journalissuearticles values(AUC>0.9);, while HCO3-, delta HCO3-, delta ratio were found to have acceptable diagnostic power insert ignore into journalissuearticles values(AUC: 0.7-0.8);. Conclusion: Delta anion gap, delta bicarbonate, and delta ratio can be used as prognostic factors in predicting mortality in MP cases.
Keywords : Metanol zehirlenmesi, delta oranı, delta anyon açığı, delta bikarbonat, mortalite