Effect of microsatellite instability on histopathological parameters and prognosis in colon cancers

Authors : Tuğba TOYRAN, Kivilcim ERDOGAN, Emine KILIÇ BAĞIR, Arbil AÇIKALIN, Merve AKSIN, Semra PAYDAŞ, Burak METE, Seyda ERDOGAN

Pages : 1-10

Doi:10.17826/cumj.1217604

View : 25 | Download : 13

Publication Date : 2023-03-31

Article Type : Research Paper

Abstract :Purpose: The aim of this study was to compare the clinicopathological features, while evaluating the frequency of MSI, and the survival rates in these patients in our patient group with MSI and microsatellite stabil insert ignore into journalissuearticles values(MSS); colorectal carcinomas insert ignore into journalissuearticles values(CRCs);. Materials and Methods: We retrospectively enrolled 146 patients who underwent colon resection between the years of 2014-2022. The expression of MSI status was evaluated by immunohistochemistry. The association of MSI status, presense of tumor-infiltrating lymphocytes insert ignore into journalissuearticles values(TILs);, and tumor budding score with a patient’s survival was assessed by the Kaplan–Meier method and Cox regression analysis. Results: There were 104 insert ignore into journalissuearticles values(71.2%); MSS cases and, 42 insert ignore into journalissuearticles values(28.8%); MSI cases. 15 insert ignore into journalissuearticles values(10.3%); MSI tumors were found to be MSI-low, and 27 insert ignore into journalissuearticles values(18.5%); to be MSI-high. MSI tumors were significantly associated with younger patients insert ignore into journalissuearticles values(<50);, earlier stage insert ignore into journalissuearticles values(T1-T2);, right localization, lower rate of lymph node metastasis, presence of mucinous component and TILs response. The Cox-regression model revealed TILs, tumor budding score, and MSI are variables that significantly affect survival. The presence of TILs exhibited a protective effect insert ignore into journalissuearticles values(Hazard ratio insert ignore into journalissuearticles values(HR);=0.446);, which decreased the mortality risk by 2.24 times for the follow-up period, while the presence of high TBS increased the risk of mortality by HR=3.22. Conclusion: This study revealed that patients with MSI CRCs may show unique clinicopathological features and should be evaluated using some guiding parameters that will improve survival.
Keywords : Kolon kanseri, mikrosatellite instabilite, histopatolojik parametre, prognoz