The level of dementia biomarkers in type 2 diabetes mellitus

Authors : Lütfiye ÖZPAK, Murat ŞAHİN, İbrahim Seyfettin ÇELİK, Bekir Mehmet KELLECİ, Mustafa ÇELİK

Pages : 825-832

Doi:10.17826/cumj.1311596

View : 38 | Download : 61

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Purpose: Like Alzheimer\`s disease, a disease of the aging world, and metastasis in cancer, it is very important to elucidate the etiology of Type 2 diabetes, which causes tissue and organ damage by systematically spreading throughout. In this study, we aimed to examine whether markers used as biomarkers in Alzheimer\`s pathogenesis are effective in the pathogenesis of diabetes. Materials and Methods: In our study, 30 type 2 diabetics, 30 type 2 diabetics individuals with the risk of dementia as a result of mini-mental test, and 28 healthy individuals aged 50-70 years were included, and brain-derived neurotrophic factor insert ignore into journalissuearticles values(BDNF);, dual-specificity tyrosine-regulated kinase 1 insert ignore into journalissuearticles values(DYRK1A);, Tau, fatty acid binding proteins 7 insert ignore into journalissuearticles values(FABP7); levels were measured from plasma samples. Results: There was a significant difference between the diabetes group with a high risk of dementia insert ignore into journalissuearticles values(MMSE < 24); and the other groups in Tau, and FABP7 levels, but no significant differences were found in BDNF and DYRK1A levels. Conclusion: These biomarkers might be used to diagnose Alzheimer\`s disease in patients with T2D and at risk of dementia before resorting to other more expensive and invasive diagnostic methods.
Keywords : Diabetes mellitus Tip 2, alzheimer hastalığı, beyin kaynaklı nörotrofik faktör, tau proteini, yağ asidi bağlayıcı protein 7, protein serin treonin kinazlar