Prevalence and resistance trends of Gram positive cocci Staphylococcus aereus and Enterococcus spp. in a tertiary care hospital

Authors : Hatice Hale GÜMÜŞ

Pages : 1177-1186

Doi:10.17826/cumj.1350843

View : 39 | Download : 41

Publication Date : 2023-09-30

Article Type : Research Paper

Abstract :Purpose: Antimicrobial resistance is a silent pandemic. In this study, it was aimed to determine the distribution and resistance trends of Staphylococcus aureus insert ignore into journalissuearticles values(S. aureus);, Enterococcus faecium insert ignore into journalissuearticles values(E. faecium); and Enterococcus faecalis insert ignore into journalissuearticles values(E. faecalis); isolates, which are among the priority pathogens of the World Health Organization in bloodstream infections. Materials and Methods: This was a retrospective study conducted between January 1, 2021 and March 31, 2023. The blood cultures insert ignore into journalissuearticles values(n=1261);, of which microbiologically tested by using an automated system, were screened in the relevant period via laboratory information system. Results: Of the total 941 isolates, 51.9% were S. aureus insert ignore into journalissuearticles values(n=488);, 22.9% were E. faecalis insert ignore into journalissuearticles values(n=216);, and 25.2% were E. faecium insert ignore into journalissuearticles values(n=237);. Of the patients, 89.1% were inpatients insert ignore into journalissuearticles values(n=838);, and 10.9% were outpatients insert ignore into journalissuearticles values(n=103);. The most of patients were hospitalized in internal medicine departments insert ignore into journalissuearticles values(53.3%); and in intensive care units insert ignore into journalissuearticles values(35%);. Among S. aureus isolates, the resistance rate to benzylpenicillin was 93.8%, to methicillin 44.3%, to teicoplanin 3.7%, and to linezolid 0.4%. Vancomycin and tigecycline resistances were not detected. Of the E. faecalis isolates, 5.5% were resistant to ampicillin, 3.3% to vancomycin, 3.2% to linezolid, and 0.7% to tigecycline. The resistance rates for E. faecium strains were 90.9% for ampicillin, 28.7% for vancomycin, 17.7% for tigecycline, 4.3% for linezolid, and 0.8% for teicoplanin. When the susceptibilities of all three bacteria were compared, a statistically significant difference was found between teicoplanin, vancomycin, tigecycline and linezolid susceptibilities. The methicillin resistance was higher in internal medicine and intensive care units. The levofloxacin and vancomycin resistance were more prevalent in intensive care units. Conclusion: MRSA insert ignore into journalissuearticles values(44.3%);, vancomycin insert ignore into journalissuearticles values(28.7%); and tigecycline insert ignore into journalissuearticles values(17.7%); resistant E. faecium rates are well above the national data. The epidemiology on resistance trends, which will guide clinicians in the management of bloodstream infections, should be carried out periodically.
Keywords : Enterococcus faecium, Enterococcus faecalis, antimikrobiyal direnç, metisilin direnci, vankomisin direnci, linezolid direnci, tigesiklin direnci, MRSA, VRSA, VRE