Chemotherapy-induced peripheral neuropathy in the neuronal cells model

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Cukurova Medical Journal
Cilt: 49 Sayı: 3
Chemotherapy-induced peripheral neuropathy in the neuronal cells model

Chemotherapy-induced peripheral neuropathy in the neuronal cells model

Pages : 858-859

View : 115 | Download : 308

Publication Date : 2024-09-30

Article Type : Other Papers

Abstract :This research aims to investigate the impacts of quercetin and low-level laser therapy (LLLT) on undifferentiated and nerve growth factor-differentiated PC12 cells experiencing cisplatin-induced peripheral neuropathy. PC12 cells treated with cisplatin were simultaneously exposed to quercetin and LLLT. We evaluated the effects of quercetin and LLLT on the expression of GAP-43 and Synapsin I genes through real-time PCR, cell viability using MTT assay, apoptosis induction via Annexin and dead assay, mitochondrial potential alterations using a mitopotential assay, and lactate dehydrogenase activity analysis in cells. Our findings revealed that cisplatin led to increased apoptosis, mitochondrial dysfunction, and LDH activity, while reducing cell viability and inhibiting the expression of GAP-43 and Synapsin I genes in both undifferentiated and differentiated PC12 cells. However, the application of quercetin and LLLT resulted in decreased apoptosis, mitochondrial potential alterations, and lactate dehydrogenase activity. We propose further investigation into the in vivo effects of quercetin and low-level laser therapy on cisplatin-induced peripheral neuropathy, as well as exploring the molecular relationship between quercetin and low-level laser therapy.
Keywords : Nöronal Hücreler, Sisplatin, Kemoterapiye bağlı periferik nöropati

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