Assessment of antioxidant efficacy of saffron-withania somnifera herbal gel against oral ulcers: an invitro study

Authors : Madhumitha Mahalingam, Devika S Pıllaı, Rajeshkumar Shanmugam

Pages : 261-269

Doi:10.17826/cumj.1563879

View : 182 | Download : 230

Publication Date : 2025-06-30

Article Type : Research Paper

Abstract :Abstract Purpose: Recurrent aphthous stomatitis (RAS) is the most commonly seen ulcerative lesion of the oral mucosa. The lesions are generally recurrent, painful and can affect the quality of life. The aim of this study was to evaluate the efficacy of herbal extracts of saffron, withania somnifera, Dry ginger, Tulsi as an antioxidant agent in RAS. Materials and Methods: 1g powder of tulsi, withania somnifera, dry ginger was mixed with 100ml of distilled water separately and boiled in a heating mantle at 50 to 60 degree for 15 minutes. Anti-inflammatory, antimicrobial, antioxidant,cytotoxic activities were tested by adding 5 ml extract to empty gel containing a combination of carboxylate methyl cellulose 5g, carbapel 5g. Antioxidant property of withania somnifera, saffron, dry ginger and tulsi were evaluated using DPPH assay, H2O2 assay and FRAP assay. Results: Our study revealed highest zone of inhibition of 90.22, 84.3, 88.93% at a concentration of 50 microgram per milliliter which is near to that of standard value Conclusion: This study gives an insight that the naturally occurring constituents of medicinal herbs will be able to resolve oral ulcers thereby improving the quality of life of the patients. Hence, herbal medicines can be used as an adjunct to synthetic drugs available commercially.
Keywords : Withania somnifera, tulsi, kuru zencefil, safran, ülser, ilaç, yaşam kalitesi

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