Assessing the TAPSE/sPAP ratio for prognostic insight in HFpEF patients

Authors : Yunus Emre Yavuz, Ahmet Taha Şahin, Sefa Tatar, Huseyin Ozer

Pages : 370-379

Doi:10.17826/cumj.1589468

View : 70 | Download : 150

Publication Date : 2025-06-30

Article Type : Research Paper

Abstract :Purpose: Heart failure with preserved ejection fraction (HFpEF) is closely associated with right heart dysfunction. Our study aimed to elucidate the association between HFpEF and the TAPSE/sPAP ratio. Materials and Methods: This retrospective observational study was conducted at a tertiary care cardiology clinic. A total of 64 patients diagnosed with HFpEF based on clinical criteria and an H2FPEF score ≥5 were included, along with 62 age- and sex-matched controls without heart failure symptoms. Demographic characteristics, laboratory markers, including NT-proBNP, and echocardiographic measurements were recorded. Particular attention was given to assessing right heart function using the TAPSE/sPAP ratio. Results: The TAPSE/sPAP ratio was lower in patients with HFpEF than in controls (median 0.76 vs. 0.96). Patients with HFpEF also had higher NT-proBNP levels (median 2136.5 pg/mL vs. 136.5 pg/mL) and higher H2FPEF scores. A TAPSE/sPAP cut-off value of 0.843 was identified, which showed 70.3% sensitivity and 72.6% specificity in distinguishing HFpEF. Correlation analysis revealed that lower TAPSE/sPAP ratios were associated with higher NT-proBNP levels, elevated H2FPEF scores, and increased left atrial volume index. Conclusion: The evaluation of the TAPSE/sPAP ratio in patients suspected of having HFpEF may be useful. Notably, TAPSE/sPAP predicted HFpEF regardless of EF in the multivariate analysis. In addition, their significant relationship with H2FPEF score and NT-proBNP levels strengthened their prognostic value.
Keywords : Ekokardiyografi, HFpEF, TAPSE, sPAP, Sağ kalp disfonksiyonu

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