A new index for predicting epileptic seizures: glucose potassium ratio

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Cukurova Medical Journal
Cilt: 50 Sayı: 2
A new index for predicting epileptic seizures: glucose potassium ratio

A new index for predicting epileptic seizures: glucose potassium ratio

Authors : Adem Köksal, Mehmet Seyfettin Sarıbaş, İbrahim Çaltekin, Ali Aygun, Şükran Kaygısız, Mesut Tomakin

Pages : 308-316

Doi:10.17826/cumj.1639560

View : 171 | Download : 179

Publication Date : 2025-06-30

Article Type : Research Paper

Abstract :Purpose: This study aimed to evaluate the glucose to potassium ratio (GPR) as a potential biomarker for diagnosing active epileptic seizures in patients presenting to the emergency department. Materials and Methods: This study was conducted at a tertiary university hospital\\\'s emergency department from January 1, 2022, to December 31, 2022. This study included patients presenting to the emergency department with generalized motor epileptic seizure activity and witnessed seizure activity (observed by health personnel) (Group A), and adult patients with a diagnosis of epilepsy visiting the neurology outpatient clinic for routine check-ups (Group B). Results: A total of 119 and 118 patients in groups A and B, respectively, were included. Significant differences were observed in white blood cell counts, glucose, potassium, and GPR levels between the groups. Receiver Operating Characteristic (ROC) curve analysis indicated that a GPR cut-off value of 24.8 had a sensitivity of 71.4% and specificity of 66.9% [Area Under the Curve (AUC)= 0.758]. Multivariate logistic regression revealed that GPR was an independent predictor of epileptic seizure activity [Odds ratio (OR)=0.873, 95% confidence intervarl (CI) 0.831–0.917). Conclusion: GPR is a promising independent biomarker for predicting active epileptic seizure activity, and is significantly associated with increased seizure episodes. This study underscores the potential of GPR as a simple, effective diagnostic tool, especially in emergency settings where advanced diagnostic methods may be unavailable. Further prospective studies are recommended to validate these findings and to assess their clinical implications.
Keywords : Epilepsi, Glukoz, Nöbetler, Potasyum

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