Immunogenetic and metabolic risk factors in male androgenetic alopecia: the role of HLA-DRB1 alleles and vitamin D3 deficiency

Authors : Tuğba Tehci, Ümit Türsen

Pages : 996-1003

Doi:10.17826/cumj.1759099

View : 91 | Download : 268

Publication Date : 2025-12-22

Article Type : Research Paper

Abstract :Purpose: Androgenetic alopecia (AGA) is the most common cause of hair loss in men. Although medically benign, it has a significant psychosocial impact on patients. The high rate of family history suggests polygenic inheritance. The current study aims to investigate HLA-DR B1 allele positivity in patients with AGA and evaluate the relationship with metabolic and dermatologic diseases that may accompany this disease and vitamin D3 deficiency. Materials and Methods: The medical records of 85 male patients diagnosed with AGA based on clinical history and physical examination were retrospectively reviewed. Patients with stage II or higher AGA according to the Hamilton-Norwood classification were included in the study. Retrospective data were analyzed and recorded through chart review. Demographic characteristics, clinical findings, laboratory results, HLA-DRB1 allele profiles, and serum vitamin D3 levels were evaluated. Additionally, concomitant metabolic and dermatological conditions were assessed in all patients. Results: In the distribution of HLA-DRB1 allele frequencies, HLA-DRB101, HLA-DRB104, and HLA-DRB111 positivity were observed more frequently. When the specific allele subtypes were analyzed, DRB104 11 was positive in 6.4%, DRB111 11 in 11.2%, and DRB111 13 in 6.4% of cases. Vitamin D3 levels were found to be low in 82% of patients with AGA. Conclusion: This study shows that AGA is associated with immunogenetic factors and vitamin D3 deficiency. Screening these parameters may guide clinicians in early diagnosis and treatment.
Keywords : Androgenetik alopesi, HLA-DRB1, metabolik sendrom, vitamin D3, immünogenetik

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