Importance of Vitamin D in COVID-19 Patients

Muharrem KÖSE; İftihar KÖKSAL; Yıldız OKUTURLAR; Özlem ÇELİK

doi:10.56016/dahudermj.1185131

Importance of Vitamin D in COVID-19 Patients

Authors : Muharrem KÖSE, İftihar KÖKSAL, Yıldız OKUTURLAR, Özlem ÇELİK

Pages : 110-113

Doi:10.56016/dahudermj.1185131

View : 36 | Download : 9

Publication Date : 2022-10-29

Article Type : Research Paper

Abstract :Objectives: The severe acute respiratory syndrome-coronavirus-2 insert ignore into journalissuearticles values(SARS-CoV-2); virus, was identified as the cause of a severe respiratory illness in Wuhan, China three years ago. The COVID-19 infection, which was declared a pandemic in March 2020, caused more than 600 million people to get sick and close to 7 million people to die. Which people have the disease more severely and who have higher mortality are still the subject of research. We investigated whether vitamin D, whose role in immunity has been known for a long time, also affects the prognosis of COVID-19 infection. COVID-19 is currently the leading cause of death worldwide. Vitamin D is an important micronutrient and has been reported to protect against respiratory diseases by improving immunity. In this study, we aimed to reveal whether the 25-hydroxyvitamin D insert ignore into journalissuearticles values(25 insert ignore into journalissuearticles values(OH); D); concentration is associated with the risk and severity of COVID-19 by evaluating vitamin D levels in outpatients or hospitalized patients with the diagnosis of COVID-19. Methods: In the study, vitamin D levels in 124 COVID-19 cases and clinical course and laboratory findings were analyzed retrospectively between March 11-May 31 2020. Statistical analysis was done using IBM SPSS 23. Kolmogorov Smirnov, Man Whitney U, Kruskal Wallis Test, Chi-square, and fisher extract and risk analysis tests were used. Categorical variables were expressed as %. P value < 0.05 was considered significant. Results: Vitamin 25 insert ignore into journalissuearticles values(OH); D level in 32 patients insert ignore into journalissuearticles values(median 10.2); who were given antiviral treatment and needed oxygen. It was found to be significantly lower than the other 92 patients insert ignore into journalissuearticles values(median 16.25);. When patients who needed oxygen treatment during COVID-19 treatment were examined in terms of vitamin D levels; It was observed that patients with 25 insert ignore into journalissuearticles values(OH); vitamin D level < 10 needed more O2 insert ignore into journalissuearticles values(OR: 2,833 CI 95% 1,230-6,528, p = 0.013);. In patients with 25 insert ignore into journalissuearticles values(OH); vitamin D < 10, more patients had pulmonary involvement with thorax CT insert ignore into journalissuearticles values(OR: 2.225 CI 95% 0.999-4.952 p = 0.048); and these patients had more back pain symptoms insert ignore into journalissuearticles values(OR: 4,765 CI 95% 1,126-20,163 p = 0.022);. Patients with 25 insert ignore into journalissuearticles values(OH); vitamin D <10 had a greater number of decreased senses of smell and taste insert ignore into journalissuearticles values(OR: 11,857 CI 95% 1,336-105,214 p = 0.006);. In addition, 25 insert ignore into journalissuearticles values(OH); vitamin D levels were positively correlated with aPTT, while it was negatively correlated with neutrophil/monocyte ratio, glucose, ALT, AST, GGT, and LDH. Conclusions: Our findings suggest a potential relationship between vitamin D concentrations and the prognosis of COVID-19 infection. Our results support the importance of vitamin D levels in the treatment of COVID-19 and the need for vitamin D supplements in treatment.
Keywords : COVID 19, vitamin D, pneumonia

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