The atherogenic index of plasma complicates the thrombotic tendency of chronic myeloproliferative disorders: A retrospective cohort study

Authors : Mine KARADENİZ, Ozge OZCAN ABACIOGLU, Ümit Yavuz MALKAN, İbrahim Celaleddin HAZNEDAROĞLU

Pages : 54-61

Doi:10.56016/dahudermj.1249255

View : 18 | Download : 11

Publication Date : 2023-04-29

Article Type : Research Paper

Abstract :Objectives: Chronic myeloproliferative diseases insert ignore into journalissuearticles values(CMPD); are neoplastic disorders leading to hypercoagulability and thrombosis. The critical hemostatic abnormalities include alterations in the blood viscosity and a history of recent thrombus. The aim of this study is to assess the interrelationships among the atherogenic index of plasma insert ignore into journalissuearticles values(AIP); and thromboembolism of CMPD with JAK2 V617F mutation. Methods: Ninety-two patients diagnosed as CMPD with JAK2 V617F mutation and 73 controls were included into the study. The patients were evaluated for the presence of any venous or arterial thromboembolic events. AIP was calculated by using the formula log insert ignore into journalissuearticles values(Tg/HDL); from serum triglyceride and high-density lipoprotein values. Results: The study group consisted of 30 patients insert ignore into journalissuearticles values(33%); with myelofibrosis insert ignore into journalissuearticles values(MF);, 42 patients insert ignore into journalissuearticles values(46%); with polycythemia vera insert ignore into journalissuearticles values(PV); and 20 patients insert ignore into journalissuearticles values(21%); with essential thrombocythemia insert ignore into journalissuearticles values(ET);. Two study groups were similar in terms of sex, age and other comorbidities insert ignore into journalissuearticles values(p > 0.05);. CMPD group had higher levels of right blood cell count insert ignore into journalissuearticles values(RBC);, red blood cell distribution width insert ignore into journalissuearticles values(RDW);, platelets insert ignore into journalissuearticles values(PLT);, hemotocrit insert ignore into journalissuearticles values(Hct); and AIP. Univariate and multivariate logistic regression analysis revealed that platelet count, RBC and AIP were independent predictors for thrombosis in both groups. The comparison of ROC curve analysis disclosed that AIP was superior to platelet count and RBC in predicting thrombosis. Conclusion: AIP can be used to determinate higher risk of thromboembolism in patients with CMPD. As a reliable and ‘easy-to-assess’ diagnostic tool, AIP could be useful for the determination of thrombotic events in CMPD clinicobiological disease course.
Keywords : atherogenic index, myeloproliferative, Janus kinase, thromboembolism