A case of recurrent acute pancreatitis following ocrelizumab use

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DAHUDER Medical Journal
Volume:4 Issue:2
A case of recurrent acute pancreatitis following ocrelizumab use

A case of recurrent acute pancreatitis following ocrelizumab use

Authors : Elif Işıklar, Berivan Akdoğan, Uygar Yavaş, İsmail Demir

Pages : 61-63

Doi:10.56016/dahudermj.1267120

View : 114 | Download : 119

Publication Date : 2024-04-29

Article Type : Other Papers

Abstract :Acute pancreatitis is an acute inflammatory process of the pancreas. Drugs are a relatively rare cause of acute pancreatitis with an incidence of 0.1-2%. Ocrelizumab is a monoclonal antibody that causes peripheral B lymphocyte suppression by targeting CD20 receptors on B lymphocytes. In this case report, we aimed to present a case of acute pancreatitis after ocrelizumab use. It is thought that suppression of B lymphocytes by ocrelizumab may induce proinflammatory cytokine release and may also cause pancreatitis by disrupting T lymphocyte regulation. Therefore, ocrelizumab should be considered in the etiology of pancreatitis in patients receiving ocrelizumab treatment.
Keywords : Ocrelizumab, Pancreatitis, MONOCLONAL ANTİBODY

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