Inhibitory Properties of Aniline, Aminophenol Compounds and their N-acetylated Derivatives on Carbonic Anhydrase

Authors : Kani Zilbeyaz, Nashia Stellenboom, Murat Guney, Murat SENTURK

Pages : 1-8

View : 23 | Download : 6

Publication Date : 2018-05-31

Article Type : Research Paper

Abstract :Carbonic anhydrases insert ignore into journalissuearticles values(CAs); are a group of metalloenzymes responsible for speeding up the conversion of carbon dioxide and water to a bicarbonate ion and a proton. CAs is divided into seven well-defined classes, namely, alpha, beta, gamma, delta, zeta, eta and theta. The alpha class of CAs is found in animal systems and is involved in various physiological and pathological processes. In some cases CA inhibition is required to treat certain disorders. Over the years metal complexing anions and sulfonamide compounds have been used extensively for this purpose. This paper investigated the potential inhibitory properties of aminophenol insert ignore into journalissuearticles values(AP); compounds and their acetylated derivatives against human cytosolic carbonic anhydrase insert ignore into journalissuearticles values(hCA); isozymes I and II. 
Keywords : Carbonic anhydrase, aminophenol, inhibitory