The Analysis of Glutathione Level and Superoxide Dismutase Activity in Normal and Preeclampsia Pregnant

Authors : Naim UZUN

Pages : 23-29

View : 18 | Download : 8

Publication Date : 2019-06-27

Article Type : Research Paper

Abstract :Preeclampsia is a disease characterized by hypertension and significant proteinuria that occurs after the twentieth week of pregnancy. The presence of mechanisms that detoxify free oxygen radicals associated with increased oxygen consumption in preeclampsia is very important. In mitochondrial and microsomal systems, molecular oxygen is reduced by taking an electron and superoxide radical is formed which is an unstable structure. Superoxide Dismutase is a metalloenzyme which converts superoxide radical to Hydrogen Peroxide. Glutathione Peroxidase degrades hydrogen peroxide by converting it into water and molecular oxygen using glutathione. Twenty-seven preeclampsia patients and 32 healthy pregnant control groups were selected at 20-28 weeks of gestation. There was a significant difference insert ignore into journalissuearticles values(p <0.05); between Superoxide dismutase and glutathione levels in patients with preeclampsia and control group. We aimed to investigate the effect of two important components of the antioxidant system, superoxide dismutase and glutathione, on preeclampsia causing fetal and maternal mortality.
Keywords : Preeclampsia, Superoxide Dismutase, Glutathione