Investigation of cholinesterase inhibitory potential of chlorinated phenols

Authors : Bahareh NOSHADİ, Tugba ERCETİN, Açelya MAVİDENİZ, Hayrettin Ozan GÜLCAN

Pages : 29-34

View : 30 | Download : 9

Publication Date : 2020-03-29

Article Type : Research Paper

Abstract :Chlorinated phenols insert ignore into journalissuearticles values(i.e., totally 19 compounds from mono-chlorophenols to pentachlorophenol); have been synthesized in large amounts and used for diverse purposes within the last century. Their worldwide application in different areas also resulted in their accumulation within the environment. Therefore, it is always a topic of concern to investigate the biological effects of these compounds by various scientific disciplines, including but not limited to, toxicology, ecology, and xenobiotic metabolism. In this study, we aimed to screen the cholinesterase inhibitory potential of chlorinated phenols. The results indicated that chlorinated phenols have low to moderate potential as inhibitors of cholinesterases and the potential depends on the substitution level of phenol.
Keywords : Cholinesterase, Chlorinated phenols, Acetylcholinesterase, Butyrylcholinesterase, xenobiotics, metaolism