Microwave assisted synthesis of ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4- dihydro-2H-furo[3,2-c]chromene-3-carboxylate via manganese(III) acetate mediated radical cyclization reaction

Authors : Negar KHEZRİ, E Vildan BURGAZ

Pages : 80-85

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Publication Date : 2020-10-31

Article Type : Research Paper

Abstract :“Ethyl 2,2-bisinsert ignore into journalissuearticles values(4-fluorophenyl);-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” is dihydro- furan-fused monocyclic heterocycles containing dihydrofurocoumarin framework. Compounds that include these core structures are especially important for drug discovery. Manganeseinsert ignore into journalissuearticles values(III); acetate has been used as an efficient oxidizing agent for the preparation of “ethyl 2,2-bisinsert ignore into journalissuearticles values(4-fluorophenyl);-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” by the multi-steps reaction of ethyl 3,3-bisinsert ignore into journalissuearticles values(4-fluorophenyl);acrylate and 4-hydroxycoumarin under microwave irradiation to perform faster heating times, significantly reduce reaction times, and the efficient solubilization of manganeseinsert ignore into journalissuearticles values(III); acetate in acetic acid. The cyclization reaction was achieved using reactivity of the carbonyl group within the molecule.
Keywords : Radical Cyclization Reaction, Manganese III, Acetate, Dihydrofuran, Microwave irradiation