INCIDENCE AND SPECTRUM OF THROMBOPHILIA IN WOMEN WITH RECURRENT PREGNANCY LOSS: A RETROSPECTIVE STUDY

Authors : Ayça KOCAAĞA, Halime KILIÇ, Sevgi GÜLEÇ

Pages : 116-120

Doi:10.48176/esmj.2023.117

View : 44 | Download : 48

Publication Date : 2023-07-28

Article Type : Research Paper

Abstract :Objective: Recurrent pregnancy loss insert ignore into journalissuearticles values(RPL);, which is generally known as >2 consecutive pregnancy losses before 20 weeks\` gestation, is seen in between 3-5% of women. The aim is to evaluate the frequency of common variants with hereditary thrombophilia; insert ignore into journalissuearticles values(Methylenetetrahydrofolate Reductase; MTHFR C677T and MTHFR A1298C polymorphisms; FV Leiden G1691A and Prothrombin G20210A mutation); in female patients with RPL. Materials and Methods: This retrospective cohort study is between the years 2020 and 2022. We investigated the frequency of the MTHFR C677T and MTHFR A1298C polymorphisms, FV Leiden G1691A and Prothrombin G20210A mutations in 380 females suffering from two or more pregnancy losses. Results: The mean age of the patients was 32.6 years insert ignore into journalissuearticles values(range: 18-46);. The most frequently observed variant in this group was a heterozygote mutation for the MTHFR677 polymorphism insert ignore into journalissuearticles values(n=163, 42.8%);. The second most common variant was MTHFR A1298C heterozygosity with a frequency of 41.1% insert ignore into journalissuearticles values(n=156);. The least common variant is FII homozygosity insert ignore into journalissuearticles values(0.3%);. Heterozygous of FII and FV Leiden insert ignore into journalissuearticles values(G1691A); mutations were found in 1.8% insert ignore into journalissuearticles values(1/380); and 8.4% insert ignore into journalissuearticles values(7/380); of the patients, respectively. Conclusion: The thrombophilic variants insert ignore into journalissuearticles values(FV Leiden G1691A and Prothrombin G20210A); seem to have an important role in RPL. Detection of an underlying thrombophilia may be important to begin early and appropriate treatment for couples suffering from RPL.
Keywords : Factor V Leiden, hereditary thrombophilia, Prothrombin, recurrent pregnancy loss, retrospective study