IMMUNOGENOMIC APPROACH TO THE CLINICAL MANAGEMENT OF COVID-19 SYNDROME

Authors : Ümit Yavuz Malkan, Olgu Erkin Çinar, Can Türk, Seyhan Türk, Ibrahim Celaleddin Haznedaroğlu

Pages : 266-279

View : 49 | Download : 106

Publication Date : 2023-10-16

Article Type : Review Paper

Abstract :The COVID-19 syndrome following the SARS-CoV-2 infection has three unique immunogenomic disease development phases; initiating, propagating, and complicating. Each COVID-19 phase has critical pathobiological correlations requiring distinct therapeutic clinical interventions. Renin-angiotensin system (RAS) genes are essential for initiating infections caused by coronavirus family members and may have a strong association with the exchange of critical immune genes, particularly IFN-family, in due course following the SARS-CoV-2 infection. This paper aims to review therapeutic protocols for COVID-19 within the concepts of our previously published three-phase model regarding the clinicopathological course of COVID-19 immune syndrome. The current treatment options have been reviewed in this synopsis within our three-phase disease schedule. Possible future drug candidates affecting the RAS are also considered from the immunogenomical perspective of the syndrome.
Keywords : COVID 19, remdesivir, paxlovid, coronavirus, covid 19 tedavisi, covid 19 sendromu