Comparative Evaluation of FXIII Val34Leu and PAI 4G/5G Polymorphisms in Women with Recurrent Pregnancy loss and spontaneous miscarriage

Authors : Ayça Kocaağa, Ece Akca Salık
Pages : 159-163
View : 35 | Download : 72
Publication Date : 2025-07-28
Article Type : Research Paper
Abstract :Introduction: Thrombophilia is a condition that increases the tendency to thrombosis and can be acquired or hereditary. If thrombophilia is present during pregnancy, it can lead to various complications such as preeclampsia, intrauterine growth retardation and miscarriage. The aim of this study was to comparatively investigate the association between FXIII Val34Leu and PAI 4G/5G polymorphism in spontaneous and recurrent pregnancy loss (RPL). Methods: A total of 536 people participated in this case-case study, including 408 women diagnosed with RPL and 128 women diagnosed with spontaneous abortion (SA) with a similiar family history. SPSS-22 was used to statistically investigate the genotype and allele frequencies of these variants and the significance between the two groups. Results: The mean age of the RPL and SA patients was 29.50 ± 5.46 and 30.02±6.03 years, respectively. The most common variant in both groups was Val/Val, while the least common variant was Leu/Leu FXIII Val34Leu. There was no significant difference in genotype and allele distributions for the Leu/Leu FXIII Val34Leu variant between RPL and SA patients (p=0.167 and 0.174). In our study, no significant difference was observed between SA and RPL groups in terms of genotype and allele frequencies of PAI-1 4G/5G polymorphism (p=0.110 and 0.092). PAI 4G/4G and FXIII Val/Val double mutations were dominant in patients with spontaneous abortion (23.4%) compared to RPL patients (21.0%). Conclusions: The absence of a significant difference in the frequency and combination of plasminogen activator inhibitor-1 4G/4G and FXIII Val/Val genetic variants in both groups suggests that these variants are important both in patients with recurrent pregnancy loss and in patients with a spontaneous abortion.
Keywords : FXIII Val34Leu, PAI-1 4G/5G, tekrarlayan gebelik kaybı, spontan düşük, trombofili.

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