Phytochemical Characterization of Achillea grandifolia Friv. Essential Oil and Its Potent Against Oxidative Damage, Acetylcholinesterase and a-Amylase

Authors : Gulmira OZEK

Pages : 671-684

View : 11 | Download : 11

Publication Date : 2018-09-01

Article Type : Research Paper

Abstract :The essential oil of Achillea grandifolia Friv. was obtained by hydrodistillation of aerial parts of the plant and analyzed with GC-FID and GC/MS techniques. The oil comprised mostly by the oxygenated monoterpenes insert ignore into journalissuearticles values(76.2 %); with a-terpinyl acetate insert ignore into journalissuearticles values(54.1 %); as main constituent. The monoterpene hydrocarbons were the second major compound group with p-cymene insert ignore into journalissuearticles values(17.7 %); as the main representative. The essential oil showed free radical scavenging activity against DPPH• radicals insert ignore into journalissuearticles values(Inh. 52 %); and ABTS+• cation radicals insert ignore into journalissuearticles values(TEAC 0.62 mM);. The oil demonstrated hypoglycemic activity via inhibition of a-amylase insert ignore into journalissuearticles values(IC50 0.15 mg/mL);. The effect of the oil on neurodegenerative disease was expressed via inhibition of AChE and found to be > 82 % of inhibition insert ignore into journalissuearticles values(an IC50 of 1.77 mg/mL);.
Keywords : Achillea grandifolia, Essential oil, GC MS, GC FID, Antioxidant, a Amylase, Acetylcholinesterase