Studies on Anticholinesterase and Antioxidant Effects of Samples from Iris L. Genus of Turkish Origin

Authors : Duygu SEVİM, Bilge ŞENER

Pages : 1-5

Doi:10.46239/ejbcs.602877

View : 25 | Download : 124

Publication Date : 2020-06-22

Article Type : Research Paper

Abstract :The genus Iris L. insert ignore into journalissuearticles values(Iridaceae); is a member of geophytes with attractive flowers. There are about 56 Iris taxa growing in Turkey, 24 of which are endemic. A survey of the literature indicates that the research carried out on Iris species are focused on the flavonoid and volatile compounds of the plant. In present study, the dichloromethane and methanol extracts prepared from the rhizomes of 47 Iris taxa growing in Turkey were investigated for their in vitro cholinesterase inhibitory effects against acetylcholinesterase insert ignore into journalissuearticles values(AChE); and butyrylcholinesterase insert ignore into journalissuearticles values(BChE); which the enzymes linked to Alzheimer’s disease s and antioxidant capacities using 2,2-diphenyl-1-picrylhydrazyl insert ignore into journalissuearticles values(DPPH); radical scavenging test as well. The Iris extracts studied have been found more active against BChE than AChE. compared with 100 μg/ml galanthamine insert ignore into journalissuearticles values(89.29 ± 0.96 %); as reference, Iris kerneriana insert ignore into journalissuearticles values(coded as Y122); and Iris pseudacorus insert ignore into journalissuearticles values(coded as Y131); methanol extracts had significant BChE inhibition effect insert ignore into journalissuearticles values(respectively, 80.22 ± 1.04 % and 53.06 ± 1.13 %); at concentration of 2 00 μg/ml. Among tested samples, methanol extracts of I. kerneriana , I. lazica , I. pseudacorus and I. suaveolens have shown remarkable antioxidant activity at concentration of 2 mg/ml for DPPH compared with gallic acid.
Keywords : Iris, Anticholinesterase, Antioxidant, Activity