Synthesis of N-(Aryl)-2-(phenylselanyl)acetamides and Their Antimicrobial Activities

Authors : Yılmaz Yıldırır, Serkan Yavuz, Hamdi Özkan, Özge Gürel

Pages : 309-315

View : 35 | Download : 5

Publication Date : 2016-06-20

Article Type : Research Paper

Abstract :Novel N -insert ignore into journalissuearticles values(aryl);-2-insert ignore into journalissuearticles values(phenylselanyl);acetamides insert ignore into journalissuearticles values( 5a -5l, 6, 7 ); were synthesized by the reaction of 2-insert ignore into journalissuearticles values(phenylselanyl);acetyl chloride with substitute arylamine derivatives in dry benzene .  The structures of these compounds were characterized by the spectroscopic methods such as FT-IR, 1 H-NMR, 13 C NMR and HRMS. Furthermore, all the synthesized compounds were tested in vitro for their antimicrobial and antifungal activity. The obtained results were compared with conventional reference antibiotics Ciprofloxacin and Griseofulvin`s results. Their antioxidant potentials were evaluated using in vitro antioxidant models known as DPPH insert ignore into journalissuearticles values(1,1-diphenyl-2-picrylhydrazyl); radical scavenging activities. Some of the tested compounds exhibited significant antibacterial, antifungal and antioxidant activities. Particularly, compound 5h showed more pronounced activity than reference antibiotics against Staphylococcus aureus . Compounds 5f and 5i showed excellent levels of antifungal activity against Penicillium roquefortii and Aspergillus niger . All the compounds showed moderate antioxidant activities.
Keywords : Selenium, antibacterial activity, antifungal activity, antioxidant activity, DPPH