Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Authors : Fatma Gökçe APAYDIN, Kaan KALTALIOĞLU, Barbaros BALABANLI, Şule COSKUN CEVHER

Pages : 399-406

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Publication Date : 2018-06-01

Article Type : Research Paper

Abstract :In this study, we investigated that the histopathological changes of rat kidney and liver tissues after cisplatin administration and potential beneficial effects of morin and hesperidin administration. Wistar rats were randomly divided in 7 groups: control, morin insert ignore into journalissuearticles values(M);, hesperidin insert ignore into journalissuearticles values(H);, cisplatin insert ignore into journalissuearticles values(CP);, cisplatin+morin insert ignore into journalissuearticles values(CP+M);, cisplatin+hesperidin insert ignore into journalissuearticles values(CP+H);, cisplatin+morin+hesperidin insert ignore into journalissuearticles values(CP+M+H);. Kidney and liver tissues were collected at the end of the experiment and were evaluated histopathological changes. Various histopathological changes in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- and co-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxic changes in cisplatin-induced groups.
Keywords : Cisplatin, Hepatotoxicity, Hesperidin, Histopathology, Morin