Genotoxicity of Two Nanoparticles: Titanium Dioxide and Zinc Oxide

Authors : Fatma ÜNAL, Funda DEMIRTAŞ KORKMAZ, Zekiye SULUDERE, Özlem EROL, Deniz YÜZBAŞIOĞLU

Pages : 948-958

Doi:10.35378/gujs.826911

View : 23 | Download : 11

Publication Date : 2021-12-01

Article Type : Research Paper

Abstract :Nanoparticles insert ignore into journalissuearticles values(NPs); and nanoparticle-based materials have been increasingly used in various consumer and medical applications. However, investigations have disclosed that some NPs may generate toxic effects in different cell types and organisms. In this study, the cytotoxic and genotoxic potential of titanium dioxide insert ignore into journalissuearticles values(TiO2); and zinc oxide insert ignore into journalissuearticles values(ZnO); NPs were examined by using four genotoxicity tests, chromosome aberrations-CAs, sister chromatid exchange-SCE, micronucleus-MN, and comet, in human lymphocytes in vitro. The results showed that both NPs significantly increased the frequency of aberrant cells, CA/Cell, SCE, and DNA damage, and decreased mitotic index in some treatments. These results demonstrated that TiO2 and ZnO NPs induce genotoxic effects. Therefore, more detailed in vitro and in vivo experiments should be conducted for the safe usage of both NPs.
Keywords : Titanium dioxide nanoparticles, Zinc oxide nanoparticles, Chromosome aberration test, Micronucleus test, Comet assay