Protective Effect of Vitamins C and E on Malathion-Induced Nephrotoxicity in Male Rats

Authors : Fatma UZUN, Yusuf KALENDER

Pages : 193-201

View : 15 | Download : 7

Publication Date : 2011-04-05

Article Type : Other Papers

Abstract :The male Wistar rats were given malathion and/or vitamin C+vitamin E daily via gavage for 4 weeks. When malathion-, vitamins C+E plus malathion-treated groups were compared to control, body and kidney weights decreased; serum urea, uric acid and creatinine levels increased significantly. Vitamins C+E plus malathion-treated group was compared to malathion-treated group there were statistically decrease in the serum urea level, while no significant changes were observed in other parameters. Light microscopic investigations revealed that both the malathion- and vitamins C+E plus malathion-treated groups exhibited histopathological changes in kidney. It appears that vitamins C and E didn’t ameliorate malathion-induce nephrotoxicity. Keywords : Organophosphate insecticide, Malathion, Nephrotoxicity, Vitamin C, Vitamin E.
Keywords : Organophosphate insecticide, Malathion, Nephrotoxicity, Vitamin C, Vitamin E