Effects of Sodium Selenite Supplementation on Lead Nitrate-induced Oxidative Stress in Lung Tissue of Diabetic and Non-diabetic Rats

Authors : Fatma APAYDIN, Suna KALENDER, Filiz DEMİR, Hatice BAŞ

Pages : 847-853

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Publication Date : 2014-01-23

Article Type : Research Paper

Abstract :In this study, diabetic and non-diabetic male rats were given to sodium selenite, lead nitrate and sodium selenite plus lead nitrate through gavage. At the end of the 4 th week, lipid peroxidation and antioxidant enzyme activities was investigated compared to control group. No significant differences were observed between control and sodium selenite treated groups. By the end of the fourth week, lead nitrate led to increase the levels of MDA, and decrease in antioxidant activities compared with the control group in diabetic and non-diabetic rats. As a result, sodium selenite significantly reduces lead nitrate induced testicular toxicity both groups.
Keywords : Lead nitrate, sodium selenite, oxidative stress, diabetes, lung