Lead Nitrate Induced Oxidative Stress in Brain Tissues of Rats: Protective Effect of Sodium Selenite

Authors : Suna KALENDER, Fatma APAYDIN, Filiz DEMİR, Hatice BAŞ

Pages : 883-889

View : 22 | Download : 10

Publication Date : 2014-04-28

Article Type : Research Paper

Abstract :Lead used in many industrial applications and it has been recognized as a toxic metal. The aim of this study is to investigate the effects of lead nitrate on brain tissues of diabetic and non-diabetic rats and the protective role of sodium selenite . Four weeks later, changes in antioxidant enzyme activities and MDA levels determined in the brain tissues. At the end of the study, we showed that lead nitrate causes oxidative stress in diabetic and non-diabetic rat brain and the sodium selenite can ameliorate this toxicity, but not protect completely.
Keywords : Lead Nitrate, Sodium selenite, Antioxidant Enzymes, Oxidative stress, Brain