Some novel antimicrobial therapeutic agents for acetylcholinesterase inhibitors; synthesis of hydroxyquinoline ester involving amino acid

Authors : İffet ŞAKIYAN, Elif AYNACI, Fatma ARSLAN, Hatice ÖĞÜTCÜ, Nurşen SARI

Pages : 11-19

View : 63 | Download : 13

Publication Date : 2015-02-23

Article Type : Other Papers

Abstract :The aim of this work was to investigate the new effective agents candidate for treatment of the Alzheimer’s disease. So, a series of new and highly active acetylcholinesterase inhibitors derived from hydroxyquinoline ester containing amino acid were synthesized. Antibacterial activities of the molecules were studied by the well-diffusion method against Listeria monocytogenes 4b, Staphylococcus aureus, Escherichia coli, Salmonella typhi H, Brucella abortus, Staphylococcus epidermis sp., Micrococcus luteus, Shigella dysenteria type 10, Bacillus cereus, Pseudomonas putida and antifungal activity against Candida albicans. All the synthesized compounds behave as inhibitors against AChE enzyme. CysEs and MetEs show more inhibition potency.
Keywords : Alzheimers disease, acetylcholinesterase, hydroxyquinoline, amino acid, inhibition

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