A Practical and Highly Efficient Synthesis of 1,2,4,5- Tetrasubstituted Imidazoles Using 2-Ethylhexanoic Acid as a Reusable Organocatalyst and Reaction Medium

Authors : Rahim HEKMATSHOAR, Mojgan KARGAR, Abdoljalil MOSTASHARİ, Zahra HASHEMİ, Fereshteh GOLİ, Farnoush MOUSAVİZADEH

Pages : 21-26

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Publication Date : 2015-02-23

Article Type : Research Paper

Abstract :2-Ethylhexanoic acid has been applied as a dual solvent-catalyst for the one-pot, four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles. This naturally occurring and widely produced fatty acid exhibited remarkable catalytic activity and was easily separated by extraction. The reusability of this catalytic media was examined up to four times and no significant drop in catalytic activity was observed. Utilizing ecofriendly, low cost and commercially available reagent, short reaction times insert ignore into journalissuearticles values(30-90 min);, very good to excellent yields insert ignore into journalissuearticles values(88-93); and straightforward workup procedure are the salient properties offered by this methodology.
Keywords : 2 ethylhexanoic acid, 1, 2, 4, 5 tetrasubstituted imidazoles, organocatalyst, multicomponent reaction