Cytotoxic Effects of Thiazolo[3,2-C]Pyrimidines Against Mcf-7 And Hepg2/C3a Carcinoma Cell Lines

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Hacettepe Journal of Biology and Chemistry
Volume:46 Issue:2
Cytotoxic Effects of Thiazolo[3,2-C]Pyrimidines Against Mcf-7 And Hepg2/C3a Carcinoma Cell Lines

Cytotoxic Effects of Thiazolo[3,2-C]Pyrimidines Against Mcf-7 And Hepg2/C3a Carcinoma Cell Lines

Authors : Arzu Birinci YILDIRIM, Esra MUTLU, Muhammet YILDIRIM

Pages : 237-246

View : 54 | Download : 8

Publication Date : 2018-06-03

Article Type : Research Paper

Abstract :I n the present study, a series of thiazolo[3,2-c]pyrimidines insert ignore into journalissuearticles values(4,5); have been produced via simple and efficient synthetic method and their in vitro cytotoxicities have been performed on human breast insert ignore into journalissuearticles values(MCF-7); and hepatocellular insert ignore into journalissuearticles values(HEPG2/C3A); adenocarcinoma cell lines. The results of these in vitro tests revealed that at least five of thiazolo[3,2-c]pyrimidines exhibited strong cytotoxic effects at very low concentrations, which were very similar or lower than that of reference anticancer agent, 5-FU, against MCF-7 and HEPG2/C3A cancer cell lines.
Keywords : Anticancer, breast cancer, Mannich cyclisation, thiazolopyrimidines

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