The In Vitro Impacts of Some Plant Extracts on Carbonic Anhydrase I, II and Paraoxonase-1

Authors : Elif Duygu KAYA, Bülent ERĞUN, Yeliz DEMİR, Zuhal ALIM, Şükrü BEYDEMİR

Pages : 51-59

View : 28 | Download : 10

Publication Date : 2019-02-01

Article Type : Research Paper

Abstract :The presented article focuses on the in vitro inhibition of plant extracts on the human carbonic anhydrase isoforms insert ignore into journalissuearticles values(hCA I and hCAII);, and paraoxonase-1 insert ignore into journalissuearticles values(PON1); activities. Five different plants insert ignore into journalissuearticles values(Alcea rosea, Foeniculum vulgare, Elettaria cardamomum, Laurus azorica and Lavandula stoechas); were selected in this study. Methanol, ethanol, and water extracts of plants were prepared and the concentration-dependent inhibition degrees were found for hCA I and hCA II isozymes and hPON1 spectrophotometrically. Thus, IC50 insert ignore into journalissuearticles values(mg/mL); values were obtained for each extract. Methanolic extract of Elettaria cardamomum has the highest inhibitory effects insert ignore into journalissuearticles values(0.032 mg/mL);. The water extracts of plants showed lower inhibitory impacts compared to the methanol and ethanol extracts.
Keywords : Carbonic anhydrase, inhibition, paraoxonase, plant extract