Naproxen Derivative Interaction Properties with ct-DNA

Authors : Nuriye Akbay, Zeynep Koksal, Tugba TaskinTok, Ayse UZGORENBARAN

Pages : 177-184

Doi:10.15671/hjbc.517481

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Publication Date : 2019-09-18

Article Type : Research Paper

Abstract :Interaction mode of a naproxen derivative insert ignore into journalissuearticles values(NH); with ct-DNA was explored by absorption and fluorescence spectroscopy. The experimental results revealed the static quenching as a result of groove binding between the naproxen derivative and ct-DNA. Computational studies were carried out to deeper understanding of the interactions. Molecular docking calculations shown that the interaction between NH and ct-DNA is resulted by groove binding. In addition to spectral data, docking studies revealed that NH-A_DNA and NH-B_DNA complexes had different interaction and conformational trends to each DNA isomer.
Keywords : Quenching, Groove binding, Naproxen, Stern Volmer