Novel Methyl 4,6-O-Benzylidene--D-Glucopyranoside Derivatives: Synthesis, Structural Characterization and Evaluation of Antibacterial Activities

Carbohydrates are the most abundant and the most diverse biopolymers in nature. Due to the importance of carbohydrates  it is necessary to develop a new method for the synthesis of carbohydrate based drugs of the current global  situation for health and disease. In this present work we demonstrate the synthesis of methyl 4,6-O-benzylidene--Dglucopyranoside  derivatives by direct acylation method. The structures of the newly prepared compounds have been characterized  and elucidated using various physico-chemical and spectroscopic methods including elemental analysis, melting  point determination, infrared and proton NMR spectroscopy. A number of acyl derivatives were prepared in order to obtain  a series of newer components for antibacterial screening experiments. These acylated derivatives were evaluated for in  vitro antibacterial screening studies against four human pathogenic bacteria by disc diffusion method.