Conventional and Microwave Assisted Synthesis of New Triazole Derivatives and Evaluation of Their Antimicrobial Activities

Authors : Zeynep ÖZDEMİR, İnci Selin DOĞAN, Mehmet Abdullah ALAGÖZ, Hasan Erdinç SELLİTEPE, Didem KART

Pages : 277-286

Doi:10.15671/hjbc.626966

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Publication Date : 2019-10-23

Article Type : Research Paper

Abstract :I n this study, four new oxime ether derivatives were synthesized and their antimicrobial activities were evaluated. At the same time, a comparison of the efficiency of the conventional method of synthesis with the microwave method was investigated. The structures of synthesized compounds were confirmed by their IR, 1H-NMR, and HRMS spectra. Antimicrobial activity of the compounds was tested against two Gr insert ignore into journalissuearticles values(+); bacteria insert ignore into journalissuearticles values(S. aureus, E. faecalis);, two Gr insert ignore into journalissuearticles values(-); bacteria insert ignore into journalissuearticles values(P. aeruginosa, E. coli);, and three yeast-like fungi insert ignore into journalissuearticles values(C. albicans, C. krusei, C. parapsilosis); by modified agar dilution method.
Keywords : Triazole, oxime ether, microwave synthesis, antimicrobial activity