The Effect of Interval Training Program on Nuclear Factor Erythroid-Derived 2-like 2 (NFE2L2/Nrf2) Gene Expression in Women

Authors : Neşe AKPINAR

Pages : 410-414

Doi:10.15671/hjbc.546962

View : 27 | Download : 7

Publication Date : 2019-12-01

Article Type : Research Paper

Abstract :Purpose in this work, to investigate whether interval training program has an effect on Nuclear factor erythroid-derived 2-like 2 insert ignore into journalissuearticles values( NFE2L2/Nrf2); gene expression in women.The research was made on 12 women. Participants were given a medium-term interval training program for 8 weeks, 3 days a week. The  blood samples of the participants were collected before and after the 8 weeks of training. RNA isolation was performed using TRIzol Reagent from peripheral blood mononuclear cells. NFE2L2 gene expression was determined by Biomark Real-Time PCR insert ignore into journalissuearticles values(RT-PCR);. The participants  was a significant increase in heart rate and maximal oxygen use capacity insert ignore into journalissuearticles values(VO 2 max ); after the exercise insert ignore into journalissuearticles values(p <0.001);. There was a significant decrease in the body weight and body mass index of women after the exercise insert ignore into journalissuearticles values(p <0.001);. There was a decrease in NFE2L2 gene expressions after 8 weeks of the training program insert ignore into journalissuearticles values(p <0.05,);. It shows that interval exercise reduces NFE2L2 gene expression in women. 
Keywords : Exercise, gene expression, NFE2L2 gene, interval training