Synthesis, characterization and antimicrobial studies of new chiral amide-Schiff base derivatives

Authors : Seda YÜKSEKDANACI, Demet ASTLEY, İhsan YAŞA

Pages : 33-39

Doi:10.15671/hjbc.520248

View : 17 | Download : 8

Publication Date : 2020-04-17

Article Type : Research Paper

Abstract :In this study, new chiral Schiff bases insert ignore into journalissuearticles values( 3 - 9 ); obtained from the reaction of chiral amide derivatives with different substituted aromatic aldehyde were synthesized. All synthesized compounds structures were characterized by FTIR, 1 H-NMR, 13 C-NMR and elemental analysis. All of the new synthesized compounds were tested in vitro against Staphylococcus aureus, Bacillus cereus , Escherichia coli , Salmonella thyphimirium , Klebsiella pneumoniae , Enterococcus faecalis , Pseudomonas aeruginosa , Candida albicans for their antibacterial and antifungal activities. All compounds have shown moderate to good antibacterial activity against Gram-positive and Gram-negative bacteria.  Among the compounds tested compound 7 showed most potent inhibitory action against test organisms.
Keywords : amino acid, amide, schiff base, antimicrobial