Designing of alternative polymeric nano-chelator for treatment in acute iron poisoning by molecular imprinting approach

Authors : Veyis KARAKOÇ

Pages : 319-331

Doi:10.15671/hjbc.723455

View : 157 | Download : 7

Publication Date : 2020-07-06

Article Type : Research Paper

Abstract :The aim of this study is to develop an alternative polymeric chelating agent for rapid and selectively removal with high capacity of Fe3+ ions from the gastrointestinal tract for the oral treatment of acute iron poisoning. For this purpose, Fe3+ imprinted polyinsert ignore into journalissuearticles values(hydroxyethyl methacrylate-N-methacryloyl-insert ignore into journalissuearticles values(l);- glutamic acid); insert ignore into journalissuearticles values(HEMA-MAGA); nanoparticles synthesized by surfactant free emülsiyon polymerization. Molecular imprinting insert ignore into journalissuearticles values(MIP); technique is used to enhance the selectivity of nanoparticles. Due to being carboxyl and amide groups on the MAGA monomer, it was chosen as a chelating agent for Fe3+ ions. Before the synthesizing of Fe3+ imprinted polymer, Fe3+ ions were complexed with MAGA and then Fe3+ imprinted nanoparticles were synthesized in the presence of this Fe3+-MAGA complexes. Polyinsert ignore into journalissuearticles values(HEMA-MAGA); nanoparticles were characterized by infrared spectroscopy insert ignore into journalissuearticles values(FTIR);, atomic force microscopy insert ignore into journalissuearticles values(AFM);. Average particle size and size distribution also determined by Zeta sizer. The specific surface area and mead diameter of the Fe3+ imprinted polyinsert ignore into journalissuearticles values(HEMA-MAGA); nanoparticles was 895 m2.g-1 and 95.3 nm, respectively. The maximum Fe3+ ions binding capacity of the polyinsert ignore into journalissuearticles values(HEMA-MAGA); nanoparticles at pH:4.0 were 206.4 mg.g-1 nanoparticles. Fe3+ removal performance of the Fe3+ imprinted polyinsert ignore into journalissuearticles values(HEMA-MAGA); nanoparticles with presence of other ions, optimum medium pH, temperature and equilibrium binding time were also investigated. Fe3+ removal studies were performed in both aqueous solution and intestinal mimicking solution.The results indicate that Fe3+ imprinted polyinsert ignore into journalissuearticles values(HEMA-MAGA); nanoparticles is an alternative chelating agent for the selective Fe3+ ions removal with a short time and very high capacity.
Keywords : Acute iron poisoning, Iron removal, Molecularly Imprinted Polymers MIP, iron imprinting, Glutamic acid

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