The role of the Cellular Antioxidant Defense System on Oxidative Stress in Acute Appendicitis

Authors : Ayetullah TEMİZ, Mesut IŞIK, Yavuz ALBAYRAK, Hatice Esra DURAN, Adem ASLAN, Yeliz DEMİR, Ayse ALBAYRAK, Mesut IŞIK, Şükrü BEYDEMİR
Pages : 69-78
Doi:10.15671/hjbc.728686
View : 49 | Download : 12
Publication Date : 2021-01-01
Article Type : Research Paper
Abstract :It is known that free radicals, their products and reactive oxygen species insert ignore into journalissuearticles values(ROS); are associated with many diseases. The study focuses on both some changes in oxidative stress factors in patients with acute appendicitis insert ignore into journalissuearticles values(AA); and the changes of GST and PON1 enzyme activities in the metabolism. This study involved control group insert ignore into journalissuearticles values(n = 31); and the study group insert ignore into journalissuearticles values(n = 52);. In the groups, some changes in oxidative stress factors and GST and PON1 enzyme activities which play an important role in metabolism were determined. There are changes in GST activity between study and control groups. The activity of the enzyme were significantly higher in AA groups insert ignore into journalissuearticles values(p < 0.01); than control. Malondialdehyde insert ignore into journalissuearticles values(MDA); levels in acute perforated appendicitis insert ignore into journalissuearticles values(PeA); groups were found significantly higher than control insert ignore into journalissuearticles values(p <0.01);. There is a negative correlation between mean platelet volume insert ignore into journalissuearticles values(MPV); and lipid peroxidation in AA patients insert ignore into journalissuearticles values(r=-0.654, p<0.01);. An increase in GSH production and GST activity provides an important defense mechanism against the oxidation of some macromolecules and may prevent oxidative stress in patients with appendicitis to some extent.
Keywords : Oxidative stress, acute appendicitis, cellular defense system, antioxidant enzyme

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