DNA/HSA Interactions and Anticancer Activity of a Palladium(II) Saccharinate Complex Bearing Ethyldiphenylphosphine

Authors : Ceyda İÇSEL

Pages : 107-116

Doi:10.15671/hjbc.836685

View : 69 | Download : 5

Publication Date : 2021-01-01

Article Type : Research Paper

Abstract :The binding interactions of cis-[Pdinsert ignore into journalissuearticles values(sac);2insert ignore into journalissuearticles values(PPh2Et);2] with DNA and HSA were comprehensively studied by a number of experimental methods and molecular docking studies. The Pdinsert ignore into journalissuearticles values(II); complex bound to AT-rich sites in the major groove of DNA, and interacted with the hydrophobic cavity of the subdomain IIA of HSA. These experimental findings were supported by molecular docking studies. The Pdinsert ignore into journalissuearticles values(II); complex had shown strong cytotoxic activity against different cancer cell lines and it also had selectivity especially for MCF-7 breast cancer cells higher than cisplatin.
Keywords : Paladyum II, Sakkarinat, Antikansr aktivite, DNA HSA bağlanma

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