The Isolation of L-Asparaginase and L-Serine Dehydratase from Bacteria

Authors : Nazif KOLANKAYA, Atilla ATALAY, Sevda GOKDENİZ

Pages : 17-23

View : 20 | Download : 9

Publication Date : 1975-05-01

Article Type : Research Paper

Abstract :Kidd 1953 first observed that certain transplanted lymphomas of mice and rats were strongly suppressed by treatment with guinea pig serum, and Broome 1961 provided evidence that L-asparaginase in the serum is the antitumoral factor. The finding by Mashburn and Wriston 1964 that L-asparaginase derived from Escherichia coli has antitumor activity similar to that of guinea pig serum opened up the possibility of large scale production of the enzyme for ultimate clinical trial.
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