Synthesis of New Pyrazole Compounds via Diketonic Michael Adducts

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Hacettepe Journal of Biology and Chemistry
Volume:50 Issue:2
Synthesis of New Pyrazole Compounds via Diketonic Michael Adducts

Synthesis of New Pyrazole Compounds via Diketonic Michael Adducts

Authors : Seda ÇINAR, Aslı EREN

Pages : 157-162

Doi:10.15671/hjbc.954044

View : 18 | Download : 24

Publication Date : 2022-02-28

Article Type : Research Paper

Abstract :Pyrazole ring containing heterocyclic molecules have been known to show biological activity. In this work, by realizing the cyclization reactions of diketonic Michael adducts, synthesis of new pyrazole compounds was accomplished. Diketonic Michael adducts were prepared in low-good yields by the addition reactions of acetylacetone to nitrovinyl arene compounds in the presence of piperidine. Pyrazole compounds were obtained in high yields via the cyclization reactions of these molecules. Structures of all the addition and the cyclization products were clarified by using 1H NMR, 13C NMR and HRMS techniques.
Keywords : Nitrovinyl arene, Michael addition, cyclization, pyrazole

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