EVALUATION AND COMPARISON OF THE ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SOME AMINO ACID METHYL ESTERS

Authors : Tuğçe Deniz KARACA, Hüseyin BALCI, Arzu AYSAN

Pages : 133-140

Doi:10.15671/hjbc.1183477

View : 22 | Download : 9

Publication Date : 2023-04-01

Article Type : Research Paper

Abstract :In this study, the antibacterial and cytotoxic activities of some amino acid methyl esters insert ignore into journalissuearticles values(L-methionine, L-phenylalanine, L-histidine, L-lysine, L-tryptophan, and L-tyrosine); were investigated. The effect of amino acid methyl ester compounds on antibacterial performance was determinated against Gram-negative and Gram-positive bacteria. The effect of amino acid esters on cell viability was investigated against cancerous and non-cancerous cell lines using the MTS assay. The results showed the substances had low antimicrobial effect on both Gram-negative and Gram-positive bacteria. In addition, it was found that the studied substances did not have a toxic effect on cell growth in non-cancerous cells. For this reason, it is thought that the results obtained will contribute to research on new synthesizable compounds based on amino acid esters and studies on drug development.
Keywords : Amino Acid Esters, Antibacterial Activity, Antiproliferative Activity, Cytotoxicity