The effect of vitamin D levels on eradication rates of Helicobacter pylori infection

Authors : Güner Kılıç, Gulce Ecem Kilic, Adnan Özkahraman, Şevki Konür, Yusuf Kayar

Pages : 28-32

Doi:10.52827/hititmedj.1332272

View : 121 | Download : 111

Publication Date : 2024-02-26

Article Type : Research Paper

Abstract :Objective: Many factors are known to play a role in the eradication of Helicobacter pylori (Hp). The aim of this study is to investigate the effect of 25(OH) vitamin D levels on the success of H. pylori eradication. Material and Method: This retrospective study included 237 patients, aged 18-85 years, who presented at the Gastroenterology Polyclinic with dyspeptic complaints which had been ongoing for at least 6 months. Patients were divided into two groups according to their 25(OH) vitamin D level as >20ng/ml and <20ng/ml. For Hp eradication, the patients were administered treatment of 1x1 320 mg gemifloxacin, 2x1 1 gr amoxicillin, and 1 x1 40 mg rabeprazole. After 1 month of treatment, faecal examination was made to determine whether or not Hp was eradicated. The eradication rates were compared between the groups with high and low level 25(OH) vitamin D. Results: The patients comprised 139 (58.6%) females and 98 (41.4%) males with a mean age of 40.9±14.1 years (range, 18-72 years). The 25(OH) vitamin D level was determined as mean 16.3±8.4 ng/mL (range, 3-42) in the whole sample, with an insufficient level seen in 211(89.0%) patients. In the comparison of 25(OH) vitamin D levels between the groups, the 25(OH) vitamin D level was determined to be 16.8±8.5 in the group with Hp eradication and 12.7±6.5 in the group without Hp eradication. The difference between the two groups was found to be statistically significant (p= 0.018). Conclusion: Before H pylori eradication treatment, it is important to maintain optimal levels of 25(OH) vitamin D, which has an effect on the effectiveness of eradication.
Keywords : Eradikasyon, Helicobacter pylori, D vitamini

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