The Effect of Serum and Follicular Fluid Fetuin-B Levels on In Vitro Fertilization Treatment

Authors : Orhan Ay, Cihan Toğrul, Ümit Görkem, Ercan Ayaz, Deniz Taşkıran
Pages : 235-243
Doi:10.52827/hititmedj.1585893
View : 35 | Download : 47
Publication Date : 2025-06-23
Article Type : Research Paper
Abstract :Objective: The aim of this study was to investigate the difference between fetuin-B levels in serum and follicular fluid of patients with unexplained infertility, polycystic ovary syndrome (PCOS) and poor ovarian response undergoing In vitro fertilization (IVF) treatment and to investigate the effect of fetuin-B levels on oocyte quality, embryo number and clinical pregnancy. Material and Method: In this prospective study, women with unexplained infertility (n=25), women with polycystic ovary syndrome (n=25), and women with poor ovarian response (n=25) who were diagnosed with infertility and started IVF treatment were included. Fetuin-B levels in serum and follicular fluid of the groups were tested using the ELISA method. In addition, the effect of the difference in fetuin-B levels between the groups on reproductive success was investigated. Results: The differences between the distributions of fetuin-B levels measured in follicular fluid were not statistically significant in all three groups (p>0.05). On the other hand, the fetuin-B level measured in serum was statistically significantly higher in the PCOS group than in the bad ovary group (p<0.05). According to the results of the Mann-Whitney U test performed as post-hoc, only the differences in serum fetuin-B levels between the PCOS group and the bad ovary group were statistically significant (p<0.05). Conclusion: No statistically significant correlation was found between serum fetuin-B and fetuin-B in follicular fluid in the PCOS group. However, in the unexplained infertility group, there was a statistically significant and negative correlation between the level of fetuin-B in the follicular fluid and the number of biochemical pregnancies as well as the number of clinical pregnancies. In this respect, fetuin-B level may have predictive value in predicting the outcome of in vitro fertilization (IVF) in the unexplained infertility group.
Keywords : Açıklanamayan kısırlık, Fetuin-B, foliküler sıvı, PKOS, tüp bebek tedavisi

ORIGINAL ARTICLE URL