Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal Model

Authors : Kaan KALTALIOĞLU

Pages : 275-280

Doi:10.17350/HJSE19030000280

View : 15 | Download : 11

Publication Date : 2022-12-31

Article Type : Research Paper

Abstract :Paracetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney. Prunus laurocerasus L. insert ignore into journalissuearticles values(PL); is an important folklore medicinal plant that has antioxidant properties. This study explores effects of PL fruit water and ethanol-water extracts administrations on oxidative stress in paracetamol-induced nephrotoxicity. For this purpose, 30 rats were divided into 5 groups: control, negative control insert ignore into journalissuearticles values(2 g/kg paracetamol);, PL fruit water extract insert ignore into journalissuearticles values(400 mg/kg PLW+ 2 g/kg paracetamol);, PL fruit ethanol-water extract insert ignore into journalissuearticles values(400 mg/kg PLEW+ 2 g/kg paracetamol); and positive control insert ignore into journalissuearticles values(150 mg/kg NAC+ 2 g/kg paracetamol);. 24 hours after the paracetamol induction, animals were sacrificed and oxidative parameters were analyzed spectrophotometrically in kidney tissue. PLW and PLEW extracts decreased MDA and NOx levels and increased SOD and CAT activities in paracetamol-induced nephrotoxicity. PL fruit extracts can restore the oxidative changes caused by paracetamol.
Keywords : Antioxidants, Nephrotoxicity, Oxidative stress, Paracetamol, Prunus laurocerasus